Porodična hiperholesterolemija (65775 pregleda)

19.12.2014 09:46 | Anonimni korisnik
Koji je uzrok nastanka porodične hiperholesterolemije?

19.12.2014 10:08 |

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Porodična hiperholesterolemija predstavlja tip-II. hiperlipoproteinemne bolesti.Ovo je nasledno, dominantno oboljenje.Uzrok bolesti je defekt receptora na površini ćelije za vezivanje i degradaciju beta-lipoproteina.

Klinička slika:
Holesterol-lipidi se talože u tkivima pa nastanu kožni i tetivni ksantomi, na rožnjači arcus senilis, ateromi se javljaju, ksantomi su nodularnog izgleda, zahvataju predeo oka, predeo kolena i Ahilove tetive.Ateroskleroza koronarnih krvnih sudova može da dovede do stanja infarkta miokarda.

Dijagnoza se postavlja na osnovu porodične anamneze, kliničke slike i laboratorijskog nalaza.Povećana koncentracija beta-lipoproteina i holesterola u serumu.

Lečenje se sprovodi dijetalnom ishranom uz restrikcije masti.Povećati fizičku aktinost, uz dodatak medikamentoznih lekova primenu u dve grupe:lovastatin i analozi koji blokiraju sintezu holesterola u jetri, i holestiramin zatim sinergični preparati koji prekidaju kruženje žučnih kiselina.

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